Laboratories

Laboratories

 

In the development of medication, pre-clinical studies and non-clinical studies are a research phase that begins before clinical trials begin (tests on humans), during which the feasibility of drug use, duplicate testing and safety data collection materials Gets The main objectives of the pre-clinical studies are to determine the safe dose for the first study in humans and to evaluate the safety profile of the product. Products may include new medical devices, medications, gene therapy solutions, and diagnostic tools. On average, only one in every 5,000 compounds that are at the stage of drug development and discovery is a valid drug.

 

  • Cell culture laboratory
  • Tissue laboratory 
  • Molecular laboratory
  • Non-Radioactive Chemistry Lab
  • Radioactive Chemistry Lab
  • surgery
  • Animal Maintenance Department
  • Pictures

Cell culture laboratory

Recognizing the magnificent and acclaimed cells of the world requires morphological, behavioral, molecular, growth and development and their interaction with each other. Before conducting in-vivo studies, it is necessary to examine the cell under external conditions(in-vitro). Cell culture requires facilities that can grow and replenish and maintain cells with the required equipment.

The Cell Culture Laboratory is located in the Pre-Clinical Laboratory. The main activities of this laboratory are isolation and culture of normal and cancerous cells and their long-term maintenance, cell survival and drug interventions, and so on.

 

Tissue laboratory 

A laboratory has been installed in the pre-clinical practice for biological interventions on animals and tissue testing after various interventions. In this laboratory, laboratory animals are kept and interventions are carried out by the researcher. The necessary equipment for testing different tissues in this laboratory is available.

 

Molecular laboratory

Nowadays, molecular imaging has expanded rapidly and has a key role in the research and applied sciences field. The molecular imaging is the interface between the biological sciences and physics, and a new look for biomedical research in order to observe the characteristics and monitor biological processes in cells, tissues and organisms using sensitive and precise modalities as well as contrasting mechanisms. It will provide a more accurate diagnosis of diseases, including cancers and neurological disorders, as well as significant help in designing treatment using information that provides users with cellular information and tissue physiology and tumor grade. Molecular imaging has different definitions and is considered as non-native, quantitative, and repeatable. Given that many pathogenic processes are characterized by altering molecular profiles or altering cellular behavior before the anatomy works,

In this way provides:

  • Ability to quickly diagnose the disease
  • Diagnosis with greater accuracy than the disease level
  • The ability to show the effect of the therapeutic effect
  • Improves our understanding of the interaction of the cell with the environment.

It is therefore predictable that the future of imaging is molecular imaging. In the pre-clinic lab, molecular imaging can be displayed according to the synthesized material by the researcher through modalities such as CT Scan, PET, Spect, and MRI.

 

Non-Radioactive Chemistry Lab 

The radio is composed of two words (radio) and (drug) that radio represents a radioactive element and a chemical is a chemical molecule carrying a radioactive element. The success of a radiopharmaceutical in the preclinical stages as well as entering into the clinical stage depends on the proper design and consideration of all aspects, except for the drug as a stable carrier of radioisotope, and the biological activity and produce the right pharmacology in the body. Molecules that may well act as radioisotope carriers, but do not have the proper biological activity and are out of reach from the final product.

As a result, the design and manufacture of radio-drug chemicals is the first step in ensuring the success of the next steps. This description is presented at the Chemistry Lab.

 

Radioactive Chemistry Lab

All the necessary processes for shooting with two PET and SPECT devices are done in this lab. These measures include determining the type of radioactive substance and label to be injected in accordance with the purpose of imaging, calculating the amount of radioactive material required, and so on.

 

Surgery

 
Due to the fact that the time interval between injection of the desired drugs to imaging is low, the surgery and the necessary steps are taken in this section. Researcher researchers can carry out surgical procedures on animal samples with the facilities provided by themselves or by the laboratory. They can also benefit from this environment if they wish to examine biological samples and imaging them.

 

 

Animal Maintenance Department

 
Animal Maintenance Department TUMS Preclinical Core Facility in a space suitable for use by all researchers and researchers is available and it is possible to keep mice, rats and rabbits. Maintenance of animal samples requiring injection of different drugs for imaging is provided in this section. 

Pictures

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