Page 45 - TPIS2022

Lecture title:

obstacles in intracellular delivery of imaging probes

ABSTRACT:

Radionuclides are effective agents in clinical diagnostics and therapy.
Effective application of radionuclides in pre-clinical and clinical studies
depends on the choice of optimal delivery platform. The most employed
carrier systems include monoclonal antibodies and their fragments, organic

and inorganic nanoparticles, and microspheres. Antibody-based delivery
systems have distinct advantage of specific binding to the antigens;
however, their use is restricted due to poor penetration into solid tumors;
which can be overcome by using antibody fragments. Nanoparticles
as radionuclide delivery platforms is rapidly developing field and advanced
hybrid radionuclide carriers with complex architecture further increases the
loading capacity, biomembrane crossing rate, and the tissue-penetration

efficiency of these molecules. However, clinical use of nanoparticles is
currently limited by their toxicity and unpredictability of patients’ responses.

5 International TPCF Preclinical Imaging Symposium (2022) 45
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