Page 25 - TPIS2022

Lecture title:
Multimodality imaging nanoprobes; diagnostic and therapeutic applications

ABSTRACT:

Background - Nanomaterials have several diagnostic and therapeutic applications in
medicine. They present exciting features for diagnostic purposes as contrast agents for MRI,
CT and Ultrasound. Fluorescence qualities of a part of these nanoparticles make them suitable
for employment in optical imaging as well. One of the incredible features of nanoparticles is
possibility of exploiting their different properties for multimodality imaging. There are a
variety of nanoparticles that have been used for multimodality imaging while they might
exhibit therapeutic effects as well.
Objective - This review aims to categorize the applications of nanoprobes in multimodality
imaging and summarize their adjunctive therapeutic effects.
Methods - PubMed, Scopus, Cochrane Library and Web of Science databases were compre-
hensively searched from inception to April 2022. Articles were screened based on the
inclusion and exclusion criteria.
Results – A wide range of nanomaterials and nanocomposite structures have been introduced
in the literature. Nanoprobes can serve as contrast agents for two or multiple imaging
modalities like MRI/ultrasound MRI/fluorescence imaging, quantum dot imaging/PET,
MRI/ quantum dot imaging/fluorescence imaging, Near Infrared fluorescence imaging/
MRI, MRI/fluorescence imaging/PET, CT/MRI/PET, CT/MRI/fluorescence imaging/
TEM, confocal microscopy/TEM, MRI/optical imaging/TEM, etc.
Conclusion- Combination of different imaging techniques leads to the ability of taking benefit
of different aspects of these systems and overcoming the deficits of one system alone. Besides
the aforementioned diagnostic applications, nanoprobes have exhibited therapeutic effects
through drug delivery, nucleic acid delivery and thermal ablation. Multimodality imaging by
nanoprobes allows better understanding of growth, developmental process, mechanism of
action and therapeutic effects on pathologies.
Keywords – Multimodality imaging; Nanomaterials; Nanoprobes; Contrast agents.

5 International TPCF Preclinical Imaging Symposium (2022) 25
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